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Likewise, ART specifically triggered ROS- and lysosomal iron-dependent cell death in pancreatic cancer cell (PDAC) lines (Lin et al., 2016

Tirzepatide mimics the action of natural incretin hormones while providing extended receptor activation, making it a novel subject for models involving type 2 diabetes , obesity , and metabolic syndrome

Among them, NOD-like receptor (NLRP3) plays a role in inflammatory body formation and activation, as well as in the regulation of transforming growth factor beta-1 (TGF1), monocyte chemoattractant protein-1 (MCP-1), and tumor necrosis factor ligand superfamily member 2 (TNFSF2), all of which contribute to vascular complications in diabetes [65]

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